نارسایی طولانی مدت عملکرد کلیه در بیماران پیوندی با اختلال عملکرد مزمن

  HR Khalkhali [1] , MSc E Hajizadeh [2] , PhD A Ghafari Moghadam [3] , MD A Kazemnezhad [4] , PhD Morad Hajiyan [5] , MSc     Received: 21 April, 2009 Accepted: 22 July, 2009  Abstract  Background & Aims: Chronic Allograft Dysfunction is a major concern for graft loss in Renal Transplant Recipients. This paper investigated the waiting time and death-censored graft survival in renal transplant recipients with chronic allograft dysfunction. The association between short-term and long-term kidney function in this patients were studied.  Materials & Methods: In a single-center retrospective study, 214 renal transplant recipients with chronic allograft dysfunction were investigated at Urmia University Hospitals from 1997 to 2005. Kidney function at each visit was assessed with GFR. We applied NKF and K/DOQI classification of chronic kidney disease staging system to determine stage of kidney disease in this group of patients. Kaplan-meiers survival analysis and log-rank test were used for data analysis.   Results: The pure death-censored graft loss was 26.6% with the mean waiting time of 81.7 months. In overall, death-censored graft loss in Pts with stage 3 at the beginning of the study (start of chronic allograft dysfunction’s process) is faster than other Pts.  Conclusion: The findings show that kidney function in the first year after transplantation is one of the main prognoses on death-censored graft loss. Therefore, care of renal transplant recipients in the first year increases long-term kidney survival.   Keywords: Chronic allograft dysfunction, Death-censored graft loss, Long-term kidney function disease, Survival analysis    Address: Department of Biostatistics, Tarbiat Modares University, Jalal Al-e-Ahmad St., Tehran, Iran Tel: (+9821) 88013030    Email: hajizadeh@modares .ac.ir  Source: UMJ 2010: 20(4): 331 ISSN: 1027-3727   [1] PhD Student in Biostatistics, Department of Biostatistics, Tarbiat Modares University, Tehran, Iran  [2] Associate Professor of Biostatistics, Department of Biostatistics, Tarbiat Modares University, Tehran, Iran (Corresponding Author)  [3] Assistant Professor of Nephrology, Imam Khomeini Hospital, Department of Nephrology , Urmia University of Medical Sciences, Urmia, Iran  [4] Professor of Biostatistics, Department of Biostatistics, Tarbiat Modares University, Tehran, Iran  [5] Research Expert, Tehran University of Medical Sciences, Tehran, Iran